PTD-DBM
A topical peptide that targets CXXC5, a brake on the Wnt pathway that drives hair growth. People apply it to the scalp, often with microneedling and valproic acid, to try to wake dormant follicles in androgenetic hair loss.
Where to buy PTD-DBM.
We track PTD-DBM across vetted vendors, but none is publicly listing a verifiable price right now. As soon as one does, it shows up here, cheapest first.
PTD-DBM
No vetted vendor is publicly listing PTD-DBM at a price we can verify yet. We don't show prices we can't stand behind, so this stays empty until one does.
Compare PTD-DBM with other peptides →What PTD-DBM actually does.
The simple version first, then a little more for the curious. No biochem degree required.
It releases a brake on the hair-growth pathway. By blocking a protein called CXXC5, it lets Wnt signaling run, which is the signal follicles need to re-enter their growth phase.
How it works
PTD-DBM is a Dishevelled-binding motif fused to a protein transduction domain (PTD) that ferries it into cells. Inside, it occupies the spot on Dishevelled where CXXC5 normally docks, so CXXC5 can no longer suppress Wnt/β-catenin signaling, the pathway that drives follicle growth.
Where it acts
It works locally in the scalp skin where it is applied, on the dermal papilla and follicle stem cells. DHT raises CXXC5 in balding scalp, so the idea is to lift that specific brake right where hair is thinning, rather than acting body-wide.
What people notice
In the research, treated skin showed new hair growth and even new follicles forming in wound-healing models. Users report slow change over months, not weeks, and usually pair it with microneedling for penetration.
Honest caveat: all of the efficacy evidence is from mouse studies out of the Choi lab at Yonsei University. There is no published human randomized trial of PTD-DBM for hair loss as of 2026. It is not an approved medicine and is sold strictly for research use only. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
PTD-DBM is applied topically to the scalp, not injected. It comes as a powder you reconstitute into a thin solution and dab onto thinning areas, very often right after microneedling so it can penetrate. The routine is below; for cycling and stacks, see the full guide.
Clean and prep the scalp
Apply to a clean, dry scalp. Many people microneedle the area first (a 0.5–1.5 mm dermaroller, 1–2 times a week) to open micro-channels that help the peptide reach the follicle.
Apply the solution
Reconstituted PTD-DBM is dosed at roughly 0.5–1 mg/mL. Dab or spray a small amount over the thinning area and massage it in lightly. A little goes a long way.
Let it absorb
Leave it on. Do not wash the scalp for several hours, ideally apply at night and rinse in the morning. Avoid shampooing right after a microneedling session.
Stay consistent and store it
Apply on your weekly schedule and keep going for months. Store the reconstituted vial in the fridge and the sealed powder in the freezer.
Typical PTD-DBM dose: roughly 0.5–1 mg/mL applied topically to the scalp once a week for the first two months, then once every 10 to 15 days through month six. It is run in cycles, usually alongside microneedling and sometimes valproic acid.
How to cycle PTD-DBM.
How long people run PTD-DBM, when to take a break, and the honest reasoning behind it.
Applied to the scalp weekly, then less often.
A cycle just means a defined run of time on the peptide, followed by a break. For PTD-DBM the common pattern is a roughly six month course, weekly at first then every 10 to 15 days, rather than applying it forever.
Why not just run it indefinitely? Mostly because the long-term human safety data does not exist yet. The cautious and widely followed approach is to run a focused multi-month block, assess, then take a break.
- Hold the schedule through your first couple of months, applying weekly at roughly even spacing.
- Step down, do not just quit cold if you want to maintain, moving to every 10 to 15 days after the loading stretch.
- Take a real break after a course before considering another. If shedding picks up or nothing changes, that is a conversation for a licensed provider.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
We haven't yet found a vendor publishing a lab certificate for PTD-DBM that we can link to directly. We don't post purity numbers we can't source. When a vendor publishes a real PTD-DBM COA, it'll show up here.
What people pair it with.
PTD-DBM is rarely run alone for hair. These are the combinations the community reaches for, all aimed at the same Wnt-driven, follicle-waking goal.
Wnt activation for hair
The pairing from the original research. PTD-DBM lifts the CXXC5 brake while valproic acid (a GSK-3β inhibitor) pushes the same Wnt/β-catenin pathway from the other side. Both are applied topically to the scalp.
View stack →Hair regrowth blend
A topical hair blend people layer for thinning. GHK-Cu adds copper-peptide support for the scalp and follicle, and Zinc Thymulin is run for its own follicle-signaling angle.
View stack →Penetration-led routine
Not a peptide stack so much as a method. Microneedling 1–2 times a week creates the channels that help PTD-DBM actually reach the dermal papilla, which is where it needs to act.
View stack →In the same corner.
Other hair and scalp peptides people compare against PTD-DBM.
Questions, answered straight.
Is PTD-DBM legal?
PTD-DBM is not an approved drug and is not sold for human use. The vendors we compare offer it strictly for research use only. As an unapproved substance it falls under WADA's S0 category, so competing athletes should steer clear. Rules vary by country, so check what applies where you are.
What does research use only actually mean?
It means the product is sold for laboratory and research purposes, not as a supplement or medicine for people. It has not been reviewed or approved for human use by the FDA. We aggregate prices and public lab data so you can see the landscape; what you do with that is between you and a licensed provider.
How do I apply it, and do I need microneedling?
It is a topical, dabbed or sprayed onto a clean scalp over the thinning areas. Microneedling is not strictly required, but most people use a 0.5–1.5 mm dermaroller 1–2 times a week because it opens channels that help the peptide reach the follicle where it needs to act.
How do I store it?
Keep the sealed, freeze-dried vial in the freezer and out of light. Once you mix it with bacteriostatic water, store it refrigerated and use it within a few weeks. Do not freeze a reconstituted vial.
How long until it works?
Slowly. The research and user reports point to change over months, not weeks, with people often judging it at the three to six month mark. There is no published human trial, so treat any timeline as a rough community estimate rather than a proven result.