The short list
Search "peptides for sleep" and you get a lot of confident claims and very little evidence. The honest version is smaller. Only a handful of peptides come up again and again in this context, and the human research behind them is thin. We are a price-comparison and lab-data site, not a seller, and we do not give medical advice. What follows is a plain look at the three peptides people actually ask about, the rationale each one rests on, and where the per-mg price lands today.
Two ideas separate these three. DSIP is named for sleep itself. Epitalon and pinealon are pineal bioregulators, meaning the case for them runs through the circadian system rather than directly through a sedative effect. None of this is settled science. Treat everything here as research-use-only background, not a protocol.
The three peptides
DSIP, the delta sleep inducing peptide
DSIP stands for delta sleep inducing peptide, which is exactly why it is the headline name in this category. It was first isolated from the blood of sleeping animals, and the original idea was that it helps promote the deep, slow-wave (delta) phase of sleep. The research since then has been mixed and mostly old, so the honest framing is that the rationale is intuitive but not proven. People who use it tend to do so qualitatively, in small amounts, rather than following any validated dose. The best per-mg price we track right now is $58/10mg = $5.8/mg (EZ Peptides), with a top listed purity of 98.383%.
See current listings and lab data on the DSIP product page.
Epitalon, a pineal bioregulator
Epitalon is a short peptide studied for its effect on the pineal gland, the part of the brain tied to melatonin and the body clock. The sleep rationale here is indirect: instead of acting like a sedative, the idea is that supporting pineal and circadian signaling could help normalize sleep timing. The research is largely from a single line of work and should be read with caution. Of the three, epitalon is the cheapest per mg we track, at $100/50mg = $2/mg (Onyx Biolabs), with a top listed purity of 99.8%.
See current listings and lab data on the epitalon product page.
Pinealon, the other pineal peptide
Pinealon is a related short peptide studied in the same circadian and pineal context, often grouped with epitalon. The reasoning is similar: the interest is in body-clock signaling rather than a direct knock-out effect. The evidence base is small. The best per-mg price we track is $69.97/20.0mg = $3.5/mg (BioLongevity Labs). We do not have a verified top purity figure to report for pinealon yet, so treat the listing on its own terms until a COA is available.
See current listings on the pinealon product page.
| Peptide | Best per-mg price | Top listed purity | Sleep rationale |
|---|---|---|---|
| DSIP | $58/10mg = $5.8/mg (EZ Peptides) | 98.383% | Named for delta sleep |
| Epitalon | $100/50mg = $2/mg (Onyx Biolabs) | 99.8% | Pineal / circadian |
| Pinealon | $69.97/20.0mg = $3.5/mg (BioLongevity Labs) | Not reported | Pineal / circadian |
How to choose and not overpay
Vial sizes differ, so a sticker price tells you almost nothing on its own. The number that matters is price per milligram. Epitalon at $2/mg looks very different from its $100 vial price once you account for the 50mg inside. Always convert to per-mg before you compare, or let the tools do it for you.
- Compare on price per mg, never on vial price. A bigger vial can be cheaper per mg even when it costs more up front.
- Look for a recent COA (certificate of analysis) with a purity figure. DSIP and epitalon both have one listed here; pinealon does not yet.
- Treat a missing purity number as a reason to ask the vendor, not a dealbreaker by itself.
- Match the amount you buy to the small, qualitative way these are typically used, rather than overstocking on an unproven peptide.
Dosing here is deliberately qualitative. There is no validated dose for sleep from us, and we do not give medical advice. This is research-use-only information.
Verify before you buy
Two minutes of checking saves money and reduces guesswork. Pull up the lab data, run the math on per-mg cost, and confirm the vendor you are looking at against the wider list before you commit.
- Read the purity numbers on our lab data page.
- Run any vial through the per-mg calculator to sanity-check the price.
- Scan the full vendor list and peptide directory to see your options.
- New to the terminology? Start with the basics.
Frequently asked.
Do peptides actually help you sleep?
The honest answer is that the evidence is limited. DSIP is named for deep sleep and epitalon and pinealon are studied around the pineal gland and body clock, but the human research is small and mixed. We report what people use and what it costs, and we do not promise a result or give medical advice.
Which sleep peptide is cheapest per mg?
Of the three we track, epitalon is the lowest at $100/50mg = $2/mg (Onyx Biolabs). Pinealon is $69.97/20.0mg = $3.5/mg (BioLongevity Labs) and DSIP is $58/10mg = $5.8/mg (EZ Peptides). Always compare on price per mg rather than vial price.
What does DSIP stand for?
DSIP stands for delta sleep inducing peptide. It was first isolated from sleeping animals, and the original idea was that it supports the deep, slow-wave phase of sleep. The research since then is mixed, so treat the name as a description of the rationale, not proof of an effect.
Why are epitalon and pinealon grouped together?
Both are short peptides studied around the pineal gland and circadian rhythm. The sleep angle for each runs through body-clock signaling rather than a direct sedative effect, which is why they tend to be discussed side by side.
How should I dose these for sleep?
We do not provide a dose. There is no validated dosing for sleep from us, and this is research-use-only information, not medical advice. People who use these tend to do so in small, qualitative amounts.