Tuftsin
The natural tetrapeptide (Thr-Lys-Pro-Arg) your body clips from its own antibodies, and the parent molecule behind Selank. People look at it for neuroinflammation and immune balance, nudging the brain's microglia toward a calmer, anti-inflammatory state.
Where to buy Tuftsin.
We track Tuftsin across vetted vendors, but none is publicly listing a verifiable price right now. As soon as one does, it shows up here, cheapest first.
Tuftsin
No vetted vendor is publicly listing Tuftsin at a price we can verify yet. We don't show prices we can't stand behind, so this stays empty until one does.
Compare Tuftsin with other peptides →What Tuftsin actually does.
The simple version first, then a little more for the curious. No biochem degree required.
It tells your immune cells to switch into a calmer, clean-up mode, boosting how macrophages and brain microglia clear debris while dialing down inflammatory signaling.
How it works
Tuftsin is a four-amino-acid fragment (Thr-Lys-Pro-Arg) released from the Fc region of immunoglobulin G. It binds neuropilin-1 and signals through the TGF-beta pathway, and it engages Fc receptors on macrophages to stimulate phagocytosis, the cellular clean-up process.
Where it acts
It acts on immune cells, macrophages in the body and microglia in the brain. In animal models it pushes microglia toward an anti-inflammatory M2 state, which is why it is studied in the context of neuroinflammation as well as infection.
What people notice
Tuftsin itself is short-acting and mostly a research tool, so first-hand reports are thin. People who run its longer-lasting analog Selank describe calmer mood and steadier focus; effects in studies build over weeks, not hours.
Honest caveat: almost all of this comes from animal and laboratory work, and the cleaner human data is on the analog Selank, not Tuftsin itself. Tuftsin is short-lived in the body, has never been an approved medicine, and is sold strictly for research use only. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
Tuftsin is an injection, given subcutaneously into fat with a tiny insulin needle. It isn't an oral peptide, and because it clears quickly many researchers reach for its longer-lasting analog Selank instead. The routine is below; for cycling and timing, see the full guide.
Reconstitute the vial
Add bacteriostatic water down the side of the vial (a 10mg vial + 2mL = 5mg/mL). Let it dissolve. Swirl gently, don't shake.
Draw your dose
On a U-100 insulin syringe, pull to your unit mark. 1mg at 5mg/mL is 20 units (0.2mL). Use the calculator if you're unsure.
Pinch and inject
Swab with alcohol, pinch a bit of fat, insert at 45–90°, push slowly. Subcutaneous into the belly is the simplest spot for a systemic peptide like this.
Rotate your sites
Move to a different spot each time so no area gets sore or lumpy. Store the vial in the fridge between doses.
The easiest spots are the belly (about 2 inches either side of the navel), the love handles, the front of the thigh, and the back of the upper arms. Rotate every injection.
Don't do the math, let the calculator do it.
This is Tuftsin's typical setup, already worked out. Change any value and the draw updates instantly.
Typical Tuftsin dose: no human protocol is established. Research handling tends to fall around 1 mg subcutaneously, used in short blocks rather than continuously. Many people choose the longer-lasting analog Selank instead because Tuftsin clears the body so quickly.
How to cycle Tuftsin.
How long people run Tuftsin, when to take a break, and the honest reasoning behind it.
Used in short blocks, not continuously.
A cycle just means a defined run of time on the peptide, followed by a break. For Tuftsin there is no community-standard cycle, simply because so few people run the parent molecule. The cautious pattern is a short, focused block rather than continuous use.
Why not just run it indefinitely? Mostly because the long-term human safety data does not exist, and because Tuftsin clears so quickly that open-ended use is awkward anyway. The sensible approach is a defined block, then a real break.
- Keep blocks short and defined rather than running it open-ended, since there is no validated long-term schedule.
- Take a real break between any blocks, the same way people cycle better-studied peptides.
- Consider the analog if you want something with an actual documented cycle; Selank fills that role in this family.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
We haven't yet found a vendor publishing a lab certificate for Tuftsin that we can link to directly. We don't post purity numbers we can't source. When a vendor publishes a real Tuftsin COA, it'll show up here.
What people pair it with.
Tuftsin is rarely run alone, and is most often discussed next to the other Russian-research nootropic peptides it is related to.
Mood & cognition
The classic nootropic pair people reach for. Selank, Tuftsin's own longer-lasting analog, leans anxiolytic; Semax leans toward focus and drive. Tuftsin sits behind this family as the parent molecule.
View stack →Brain support
A recovery-minded combination. Cerebrolysin supplies neurotrophic fragments while Selank adds the calmer, anti-anxiety angle. Run by people focused on cognition after stress or strain.
View stack →Inflammation focus
An immune-leaning pairing. Tuftsin nudges macrophages and microglia toward clean-up mode while Thymosin alpha-1 is run for broader immune support. Strictly exploratory, with thin human data.
View stack →In the same corner.
Other cognitive and nootropic peptides people compare against Tuftsin.
Questions, answered straight.
Is Tuftsin legal?
Tuftsin isn't an approved drug, and it isn't sold for human use. The vendors we compare offer it strictly for research use only. It isn't specifically named on WADA's prohibited list, but related immunomodulators draw scrutiny, so competing athletes should be cautious and check the current rules. Laws vary by country, so check what applies where you are.
What does research use only actually mean?
It means the product is sold for laboratory and research purposes, not as a supplement or medicine for people. It hasn't been reviewed or approved for human use by the FDA. We aggregate prices and public lab data so you can see the landscape; what you do with that is between you and a licensed provider.
How is Tuftsin different from Selank?
Selank is Tuftsin with a Pro-Gly-Pro tail added, which makes it far more stable. Tuftsin is the natural four-amino-acid parent and clears the body quickly; Selank lasts longer and has the cleaner human research behind it. Most people interested in this family run Selank, not Tuftsin itself.
How do I store it?
Keep the sealed, freeze-dried vial in the fridge, and out of direct light. Once you mix it with bacteriostatic water, store it refrigerated and use it within a few weeks. Don't freeze a reconstituted vial.
Subcutaneous or oral?
Subcutaneous. Tuftsin is a small peptide that does not survive digestion, so there is no meaningful oral version. After reconstitution it's a simple subcutaneous draw into the belly. If you want something longer-lasting in the same family, look at Selank.