5-Amino-1MQ
A small-molecule inhibitor of the enzyme NNMT, taken as an oral capsule. People run it to nudge fat cells back into burning fuel, support NAD+ levels, and back a metabolic or longevity protocol, often alongside MOTS-c and NAD+.
Where to buy 5-Amino-1MQ, cheapest first.
Prices from 6 vendors across the market. We link straight to each vendor’s product page and grade vendors on public lab data, so you’re not just chasing the lowest number.
5-Amino-1MQ
What 5-Amino-1MQ actually does.
The simple version first, then a little more for the curious. No biochem degree required.
It blocks an enzyme that lets fat cells hoard energy and drain NAD+, so cells get their fuel back and tip toward burning fat instead of storing it.
How it works
5-Amino-1MQ selectively inhibits nicotinamide N-methyltransferase (NNMT). NNMT is overactive in fat and aging tissue, where it burns through methyl groups and drags down NAD+. Blocking it is studied for restoring NAD+ and reactivating cellular energy pathways.
Where it acts
It is a small membrane-permeable molecule (about 159 Da), so it crosses cell membranes easily after an oral dose. Most of the studied action is in fat cells and metabolically active tissue, where NNMT tends to run high.
What people notice
People run it for gradual fat loss, steadier energy, and metabolic support as part of a longevity stack. Reported effects build over weeks of consistent dosing, not in a single day, and it is not a stimulant.
Honest caveat: nearly all of this comes from animal and lab studies. An 11-day mouse study showed weight loss versus controls, but there are no published human trials establishing benefit or an official dose. It is not an approved medicine and is sold strictly for research use only. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
5-Amino-1MQ is taken orally as a capsule. It is a small molecule with good oral absorption, so there is no needle, no vial, and no reconstitution. The routine is below; for cycling and timing, see the full guide.
Take your dose
A common starting dose is 50 mg once daily by mouth. Many people later move to 100 mg/day, taken as one dose or split into two (for example 50 mg morning and 50 mg midday).
Timing
Take it in the morning, with or without food. If your stomach is sensitive, taking it with a meal tends to settle early nausea. It is not stimulating, so morning dosing is about consistency, not sleep.
Stay consistent
Take it at the same time each day. Effects on body composition and energy build over weeks, so steady daily dosing matters more than any single dose.
Store it
Keep the capsules cool, dry, and out of direct light. No refrigeration or mixing needed.
Typical 5-Amino-1MQ dose: about 50 mg once daily to start, increasing to 100 mg/day if well tolerated, run in cycles of roughly 8 to 12 weeks with a break afterward rather than continuously.
How to cycle 5-Amino-1MQ.
How long people run 5-Amino-1MQ, when to take a break, and the honest reasoning behind it.
Run in cycles with a break afterward.
A cycle just means a defined run of time on the compound, followed by a break. For 5-Amino-1MQ the common pattern is roughly 8 to 12 weeks on, then a 2 to 4 week break, rather than running it indefinitely.
Why not just run it forever? Mostly because the long-term human safety data does not exist yet, and a break gives NAD+ metabolism a chance to settle. The cautious and widely followed approach is to run a focused block, then stop and reassess.
- Start at 50 mg for the first week or two before moving up, rather than opening at the top of the range.
- Hold a steady daily dose through the cycle at the same time each day, since effects build over weeks.
- Take a real break of a few weeks after a cycle before considering another. If goals or symptoms change, that is a conversation for a licensed provider.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
For 2 of these vendors we link the per-batch certificate itself (a specific lab report, COA PDF, or certificate image), and the purity below is read straight off that certificate. The rest link to the vendor's general lab-results page. We don't run the labs ourselves and we don't show a purity number unless it's printed on a certificate we link, so you can open the document and check it against the batch yourself.
| Vendor | Purity (per COA) | Batch / report | Certificate |
|---|---|---|---|
| EZ Peptides | see COA | EZP-AMINOMQ5004162026-03 | Janoshik report ↗ |
| Midwest Peptide | 99.67% | MP5AM001 | View COA ↗ |
| Penguin Peptides | see lab page | not shown | Lab results ↗ |
What people pair it with.
5-Amino-1MQ is often run inside a metabolic or longevity stack. These are the combinations the community reaches for when energy and body composition are the goal.
Energy & fat metabolism
The popular energy-and-metabolism blend. NAD+ supplies the fuel, MOTS-c signals cells to burn it, and 5-Amino-1MQ blocks the NNMT brake that drains NAD+ and favors fat storage. The three work on different steps rather than competing.
View stack →Body recomposition
A leaner two-part pairing for body recomposition. 5-Amino-1MQ removes the metabolic brake while MOTS-c pushes fat oxidation, so the two complement each other on a cut without overlapping mechanisms.
View stack →NAD+ & aging support
A longevity-leaning combination. NAD+ and 5-Amino-1MQ support cellular energy metabolism while Epitalon is run for the broader anti-aging and sleep angle. People treat this as a maintenance protocol rather than a hard cut.
View stack →In the same corner.
Other longevity and metabolic compounds people compare against 5-Amino-1MQ.
Questions, answered straight.
Is 5-Amino-1MQ legal?
5-Amino-1MQ is not an approved drug and is not sold for human use. The vendors we compare offer it strictly for research use only. It also falls under WADA's S0 non-approved substances category, so it is prohibited for competing athletes. Rules vary by country, so check what applies where you are.
Is 5-Amino-1MQ a peptide?
Not technically. It is a small quinolinium molecule (about 159 Da) that inhibits the NNMT enzyme, not a chain of amino acids. It gets grouped with peptides because the same community runs it inside metabolic and longevity stacks, but chemically it is a small-molecule inhibitor.
With or without food?
Either works, since it has good oral absorption. If you get mild nausea or stomach upset early on, especially on an empty stomach, taking it with a meal usually helps. Most people dose it in the morning for consistency.
How long until it works?
Effects on energy and body composition build over weeks, not days. People typically run a full cycle of 8 to 12 weeks before judging it, often alongside diet and training. It is not an overnight switch and it is not a stimulant.
How do people dose it?
A common pattern is 50 mg once daily to start, moving to 100 mg/day if well tolerated, taken as one dose or split into two. It is run in cycles of roughly 8 to 12 weeks with a break afterward, since there is no human trial data to set an official long-term dose.