Sermorelin
A synthetic copy of the first 29 amino acids of growth hormone-releasing hormone. People run it to nudge their own pituitary into releasing more growth hormone, usually with a small shot before bed, for recovery, body composition, and sleep.
Where to buy Sermorelin, cheapest first.
Prices from 6 vendors across the market. We link straight to each vendor’s product page and grade vendors on public lab data, so you’re not just chasing the lowest number.
Sermorelin
What Sermorelin actually does.
The simple version first, then a little more for the curious. No biochem degree required.
It taps your pituitary on the shoulder to release your own growth hormone in natural pulses, rather than injecting growth hormone directly, so your body's own feedback loops stay in charge.
How it works
Sermorelin is the active 1-29 fragment of growth hormone-releasing hormone (GHRH). It binds GHRH receptors on the pituitary and signals it to make and release growth hormone, which the liver then turns into IGF-1.
Where it acts
It works upstream at the pituitary, not on muscle or fat directly. Because it prompts your own pulsatile release, somatostatin feedback still applies, so the body can throttle the signal rather than being flooded the way it is by injected growth hormone.
What people notice
Reports center on deeper sleep, easier recovery from training, and gradual shifts in body composition over months. Effects build slowly and depend heavily on consistent nightly dosing, not single shots.
Honest caveat: the older human data is mostly from sermorelin's former use as a diagnostic and pediatric growth agent, not from the anti-aging and physique uses people run it for now. Outcomes like fat loss and muscle gain are largely anecdotal or extrapolated. It is not an approved medicine for these uses and is sold strictly for research use only. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
Sermorelin is an injection, given subcutaneously into fat with a tiny insulin needle, almost always at night before sleep to ride your natural growth hormone pulse. It isn't an oral peptide, so the injectable form is what people run. The routine is below; for cycling and timing, see the full guide.
Reconstitute the vial
Add bacteriostatic water down the side of the vial (a 5mg vial + 2.5mL = 2mg/mL). Let it dissolve. Swirl gently, don't shake.
Draw your dose
On a U-100 insulin syringe, pull to your unit mark. 200mcg at 2mg/mL is 10 units (0.1mL). Use the calculator if you're unsure.
Pinch and inject
Swab with alcohol, pinch a bit of fat, insert at 45–90°, push slowly, then hold a few seconds. The abdomen, a couple inches either side of the navel, is simplest. Dose on an empty stomach before bed.
Rotate your sites
Move to a different spot each time so no area gets sore or lumpy. Store the vial in the fridge between doses.
The easiest spots are the belly (about 2 inches either side of the navel), the love handles, the front of the thigh, and the back of the upper arms. Rotate every injection.
Don't do the math, let the calculator do it.
This is Sermorelin's typical setup, already worked out. Change any value and the draw updates instantly.
Typical Sermorelin dose: about 200–300 mcg once nightly before bed, often 5 nights on and 2 off, run for roughly 3 to 6 months before a break. It's dosed daily, not in big weekly shots.
How to cycle Sermorelin.
How long people run Sermorelin, when to take a break, and the honest reasoning behind it.
Often 5 nights on, 2 off, before a longer break.
A cycle just means a defined run of time on the peptide, followed by a break. For sermorelin the common pattern is to run it nightly for roughly 3 to 6 months, then take several weeks off before considering another block.
Why not just run it forever? Partly because the receptors can become less responsive over time, and partly because the long-term human safety data for this use does not exist. The cautious approach is a focused block, then a real break so your own signaling resets.
- Hold the nightly schedule through your block, dosing before bed at roughly the same time each night.
- Use weekly breaks, like 5 nights on and 2 off, which many people fold in to keep the pituitary responsive.
- Take a real break of several weeks after a 3 to 6 month block before considering another. If you are chasing a specific goal, that is a conversation for a licensed provider.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
For 2 of these vendors we link the per-batch certificate itself (a specific lab report, COA PDF, or certificate image), and the purity below is read straight off that certificate. The rest link to the vendor's general lab-results page. We don't run the labs ourselves and we don't show a purity number unless it's printed on a certificate we link, so you can open the document and check it against the batch yourself.
| Vendor | Purity (per COA) | Batch / report | Certificate |
|---|---|---|---|
| EZ Peptides | 99.071% | EZP-SER0505052026-05 | Janoshik report ↗ |
| Swiss Chems | 99.68% | not shown | View COA ↗ |
| Next Gen Peptides | see lab page | not shown | Lab results ↗ |
| Onyx Biolabs | see lab page | not shown | Lab results ↗ |
| Penguin Peptides | see lab page | not shown | Lab results ↗ |
What people pair it with.
Sermorelin is often paired with a ghrelin-mimetic so the two hit growth hormone release through different doors at once. These are the combinations the community reaches for.
Clean GH support
The popular beginner-friendly pair. Sermorelin nudges the pituitary as a GHRH analog, while Ipamorelin adds a clean ghrelin-mimetic pulse with minimal effect on cortisol or hunger. Both run nightly.
View stack →Longer GH signal
Stacks two GHRH-side compounds. CJC-1295 (no DAC) extends the release window while sermorelin works alongside it. People run this for a stronger, longer nightly pulse.
View stack →Stronger pulse
Pairs the GHRH analog with a stronger growth hormone-releasing peptide. GHRP-2 drives a bigger pulse but can bump appetite and cortisol slightly, so people who want maximum signal use it over Ipamorelin.
View stack →In the same corner.
Other growth hormone peptides people compare against Sermorelin.
Questions, answered straight.
Is Sermorelin legal?
Sermorelin once had FDA approval as a diagnostic and pediatric growth agent, but that product was withdrawn from the market, and it isn't approved for the anti-aging or physique uses people run it for now. The vendors we compare offer it strictly for research use only. It's also on WADA's prohibited list under S2, so competing athletes should steer clear. Rules vary by country, so check what applies where you are.
What does research use only actually mean?
It means the product is sold for laboratory and research purposes, not as a supplement or medicine for people. It hasn't been reviewed or approved for these uses by the FDA. We aggregate prices and public lab data so you can see the landscape; what you do with that is between you and a licensed provider.
How do I store it?
Keep the sealed, freeze-dried vial in the fridge and out of direct light. Once you mix it with bacteriostatic water, store it refrigerated and use it within about two weeks. Don't freeze a reconstituted vial.
Why before bed?
Your biggest natural growth hormone pulse happens in early deep sleep. Dosing sermorelin at night on an empty stomach is meant to ride and amplify that pulse rather than fight it. A big carb-heavy meal right before can blunt the release.
How is it different from injected HGH?
HGH puts growth hormone straight into your blood and overrides your feedback loops. Sermorelin instead signals your own pituitary to release growth hormone in natural pulses, so somatostatin can still throttle it. That's why people consider it gentler, though also slower and less dramatic.