FOXO4-DRI
A lab-made senolytic peptide built to clear senescent cells, the worn-out "zombie" cells that build up with age. People run short pulsed courses in the hope of clearing that cellular debris and tipping the body back toward a younger profile. The evidence is striking in mice and essentially absent in humans.
Where to buy FOXO4-DRI, cheapest first.
Prices from 2 vendors across the market. We link straight to each vendor’s product page and grade vendors on public lab data, so you’re not just chasing the lowest number.
What FOXO4-DRI actually does.
The simple version first, then a little more for the curious. No biochem degree required.
It targets senescent "zombie" cells and pushes them to self-destruct, while leaving healthy cells alone, so the body can clear out the aged cells that drive inflammation and decline.
How it works
Senescent cells survive by using the protein FOXO4 to keep p53, a cell's built-in self-destruct switch, locked away from the mitochondria. FOXO4-DRI is a decoy that blocks the FOXO4 to p53 connection, freeing p53 to trigger apoptosis (programmed cell death) in those cells.
Where it acts
It works body-wide through the bloodstream, but the effect is selective. Healthy cells are not relying on the FOXO4 to p53 trick to stay alive, so they are largely spared. The target is the small population of aged, inflammatory cells that accumulate over time.
What people hope for
In aged mice, clearing senescent cells restored fur density, kidney function, and physical fitness. People run it hoping for similar systemic rejuvenation, though that human leap is entirely unproven and is the whole reason to be cautious.
Honest caveat: the headline results come from a single line of mouse and lab research, above all the 2017 Baar study in Cell. There are no human clinical trials, no human dosing data, and a huge gap between the mouse doses and what people actually inject. Because it pushes cells toward death, getting the dose or selectivity wrong is a real concern. It is not an approved medicine and is sold strictly for research use only. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
FOXO4-DRI is an injection, given subcutaneously into fat with a tiny insulin needle. It isn't an oral peptide, so the injectable form is what people run, in short pulsed courses rather than daily forever. The routine is below; for cycling and the honest evidence picture, see the full guide.
Reconstitute the vial
Add bacteriostatic water down the side of the vial (a 10mg vial + 2mL = 5mg/mL). Let it dissolve. Swirl gently, don't shake.
Draw your dose
On a U-100 insulin syringe, pull to your unit mark. 1mg at 5mg/mL is 20 units (0.2mL). Use the calculator if you're unsure.
Pinch and inject
Swab with alcohol, pinch a bit of fat, insert at 45–90°, push slowly. Subcutaneous into the belly is the standard route for this peptide.
Pulse, don't run it daily forever
Most people dose for a short block, often 5 days on and 2 off across one or two weeks, then stop. Rotate sites and store the vial in the fridge between doses.
The easiest spots are the belly (about 2 inches either side of the navel), the love handles, the front of the thigh, and the back of the upper arms. Rotate every injection.
Don't do the math, let the calculator do it.
This is FOXO4-DRI's typical setup, already worked out. Change any value and the draw updates instantly.
Typical FOXO4-DRI dose: in community protocols, roughly 1 mg subcutaneously each morning, 5 days on and 2 days off, for a 1 to 2 week course, repeated only a few times a year. There is no validated human dose, so this is extrapolated from animal work, not established medicine.
How to cycle FOXO4-DRI.
How long people run FOXO4-DRI, when to take a break, and the honest reasoning behind it.
A short senolytic course, repeated periodically.
A cycle just means a defined run of time on the peptide, followed by a break. For FOXO4-DRI the common pattern is a short pulse of one to two weeks, then a long stretch off, repeated only a couple of times a year, rather than anything ongoing.
Why not run it longer? Because it works by pushing cells toward death and there is no human safety data at all. The cautious and widely followed approach is a brief, infrequent course, which also matches how the senolytic idea is supposed to work: clear the debris, then let the body recover.
- Keep courses short, typically one to two weeks of daily dosing, then stop completely.
- Leave long gaps, months between pulses, repeating only a few times a year at most.
- Do not stack senolytics blindly. If symptoms or concerns come up, that is a conversation for a licensed provider, not a forum.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
For one of these vendors we link the per-batch certificate itself, and the purity below is read straight off it. The rest link to the vendor's general lab-results page. We don't run the labs ourselves and we don't show a purity number unless it's printed on a certificate we link, so you can open the document and check it against the batch yourself.
| Vendor | Purity (per COA) | Batch / report | Certificate |
|---|---|---|---|
| BioLongevity Labs | 99.76% | 261245 | View COA ↗ |
What people pair it with.
FOXO4-DRI is usually run on its own and then sequenced with other compounds, not blended into a single shot. The idea most people follow is clear the old cells first, then rebuild.
Senolytic then repair
Run the FOXO4-DRI pulse first, then follow with NAD+ a couple of weeks later to support the healthy cells that remain. Sequenced, not co-injected. There's no published research on the combination, this is a community pattern.
View stack →Aging-focused stack
A senolytic pulse followed by an Epitalon course, which people run for telomere and circadian support. Two separate protocols spaced apart rather than a true stack.
View stack →Cell-energy pairing
After clearing senescent cells, some people run mitochondrial peptides like MOTS-c or SS-31 to support energy metabolism in the cells left behind. Sequenced over weeks, with no combination data behind it.
View stack →In the same corner.
Other longevity and cellular-health peptides people compare against FOXO4-DRI.
Questions, answered straight.
Is FOXO4-DRI legal?
FOXO4-DRI isn't an approved drug, and it isn't sold for human use. The vendors we compare offer it strictly for research use only. It is not currently named on WADA's prohibited list, but anti-doping rules change, so competing athletes should check. Rules vary by country, so check what applies where you are.
What does research use only actually mean?
It means the product is sold for laboratory and research purposes, not as a supplement or medicine for people. It hasn't been reviewed or approved for human use by the FDA. We aggregate prices and public lab data so you can see the landscape; what you do with that is between you and a licensed provider.
How strong is the evidence in humans?
Honestly, there isn't any yet. The exciting results, restored fur, kidney function, and fitness, come from aged mice in the 2017 Baar study and follow-up animal work. There are no human clinical trials and no human dosing data, so everything people do with it is extrapolation. That's the single most important thing to understand about this peptide.
How do people dose and cycle it?
A common community pattern is about 1 mg subcutaneously each morning, 5 days on and 2 days off, for a 1 to 2 week course, repeated only a couple of times a year rather than run continuously. Because the peptide pushes cells toward death, people keep courses short. Use the calculator to turn your vial and dose into exact units.
How do I store it?
Keep the sealed, freeze-dried vial in the fridge and out of direct light. Once you mix it with bacteriostatic water, store it refrigerated and use it within a few weeks. Don't freeze a reconstituted vial.