Humanin
A 24-amino-acid peptide encoded inside your own mitochondrial DNA. People run it for cellular resilience, studied for protecting neurons, supporting metabolism, and the mitochondrial side of aging, often alongside MOTS-c in a longevity stack.
Where to buy Humanin, cheapest first.
Prices from 2 vendors across the market. We link straight to each vendor’s product page and grade vendors on public lab data, so you’re not just chasing the lowest number.
What Humanin actually does.
The simple version first, then a little more for the curious. No biochem degree required.
It acts like a built-in survival signal for your cells, telling stressed cells not to self-destruct and helping mitochondria keep producing energy under pressure.
How it works
Humanin is a mitochondrial-derived peptide. Outside the cell it activates a receptor complex (CNTFR/WSX-1/gp130) that switches on STAT3 survival signaling. Inside the cell it blocks pro-apoptotic proteins like BAX and IGFBP-3, which is how it keeps stressed cells from dying.
Where it acts
It circulates in the blood and acts body-wide, with the most-studied effects in neurons, pancreatic beta cells, and blood vessels. Levels naturally fall with age, which is why it sits in the longevity and mitochondrial-health conversation.
What people notice
Humanin is subtle and systemic, not something you feel in an afternoon. People run it for the long game, cellular stress resilience and metabolic support, and any effects are expected to build slowly over a cycle rather than day to day.
Honest caveat: almost all of this comes from cell and animal studies. There is no completed human clinical trial using Humanin or its HNG analog as a therapy, so the mechanisms above are what it is studied for, not proven outcomes in people. It is not an approved medicine and is sold strictly for research use only. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
Humanin is an injection, given subcutaneously into fat with a tiny insulin needle. It isn't an oral peptide, since it would not survive digestion, so the injectable form is what people run. The routine is below; for cycling and timing, see the full guide.
Reconstitute the vial
Add bacteriostatic water down the side of the vial (a 10mg vial + 2mL = 5mg/mL). Let it dissolve. Swirl gently, don't shake.
Draw your dose
On a U-100 insulin syringe, pull to your unit mark. 1mg at 5mg/mL is 20 units (0.2mL). Use the calculator if you're unsure.
Pinch and inject
Swab with alcohol, pinch a bit of fat, insert at 45–90°, push slowly. Subcutaneous into the belly is simplest. Most people run native Humanin once daily during a cycle.
Rotate your sites
Move to a different spot each time so no area gets sore or lumpy. Store the vial in the fridge between doses.
The easiest spots are the belly (about 2 inches either side of the navel), the love handles, the front of the thigh, and the back of the upper arms. Rotate every injection.
Don't do the math, let the calculator do it.
This is Humanin's typical setup, already worked out. Change any value and the draw updates instantly.
Typical Humanin dose: for native Humanin, about 1 mg subcutaneously once daily, cycled roughly 4 to 8 weeks on then a break. The potent HNG analog is dosed far lower, in micrograms, so know which form you have before you draw.
How to cycle Humanin.
How long people run Humanin, when to take a break, and the honest reasoning behind it.
Cycled, not run continuously.
A cycle just means a defined run of time on the peptide, followed by a break. For Humanin the common pattern is a block of roughly 4 to 8 weeks, then time off, rather than running it indefinitely.
Why not just run it forever? Mostly because the long-term human safety data does not exist yet, and nobody knows the effect of keeping a survival-signaling peptide elevated for months on end. The cautious and widely followed approach is a focused block, then a pause.
- Hold a steady daily schedule through your cycle, dosing at roughly the same time each day.
- Take a real break after each block before considering another, rather than running it continuously.
- Re-confirm your form and units at the start of every cycle, especially if you switched vials between native Humanin and HNG.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
We haven't yet found a vendor publishing a lab certificate for Humanin that we can link to directly. We don't post purity numbers we can't source. When a vendor publishes a real Humanin COA, it'll show up here.
What people pair it with.
Humanin is usually run as part of a mitochondrial or longevity protocol rather than alone. These are the combinations people reach for.
Cellular energy
The two best-known mitochondrial-derived peptides run together. Humanin leans toward cell survival and neuroprotection; MOTS-c toward metabolism and exercise-like signaling. The go-to mitochondrial duo.
View stack →Aging & resilience
A broader anti-aging protocol. Adds Epitalon for its telomere and circadian angle on top of the mitochondrial base. Run in cycles, not continuously.
View stack →Mitochondrial defense
Pairs Humanin's survival signaling with SS-31, which targets the inner mitochondrial membrane directly. People run it when the focus is squarely on mitochondrial protection.
View stack →In the same corner.
Other longevity and mitochondrial peptides people compare against Humanin.
Questions, answered straight.
Is Humanin legal?
Humanin isn't an approved drug, and it isn't sold for human use. The vendors we compare offer it strictly for research use only. It is not named on the WADA prohibited list, but WADA's strict-liability rules mean competing athletes should be cautious. Rules vary by country, so check what applies where you are.
What does research use only actually mean?
It means the product is sold for laboratory and research purposes, not as a supplement or medicine for people. It hasn't been reviewed or approved for human use by the FDA. We aggregate prices and public lab data so you can see the landscape; what you do with that is between you and a licensed provider.
What's the difference between Humanin and HNG?
Native Humanin is the natural 24-amino-acid sequence. HNG (also called S14G-Humanin) is a synthetic analog that is roughly 1,000 times more potent and clears more slowly. That potency gap matters a lot for dosing: native Humanin is run in milligrams, HNG in micrograms. Using native-Humanin numbers with an HNG vial would be a serious overdose, so always confirm which form you have.
How do I store it?
Keep the sealed, freeze-dried vial in the fridge, and out of direct light. Once you mix it with bacteriostatic water, store it refrigerated and use it within a few weeks. Don't freeze a reconstituted vial.
How quickly does it work?
Humanin is a longevity peptide, not something you feel in a session. Any effects are expected to build slowly over a cycle of several weeks. Honestly, the human evidence is thin, so set expectations accordingly and treat it as experimental.