Klotho
A lab-made version of the body's own anti-aging protein. Levels of natural Klotho fall as we get older, and researchers run it for cognition, kidney support, and healthy aging, often as the centerpiece of a longevity stack.
Where to buy Klotho.
We track Klotho across vetted vendors, but none is publicly listing a verifiable price right now. As soon as one does, it shows up here, cheapest first.
Klotho
No vetted vendor is publicly listing Klotho at a price we can verify yet. We don't show prices we can't stand behind, so this stays empty until one does.
Compare Klotho with other peptides →What Klotho actually does.
The simple version first, then a little more for the curious. No biochem degree required.
Klotho is a protein your body makes less of as you age. Topping it back up is studied for protecting the brain and kidneys and quieting the inflammation and scarring that come with aging.
How it works
Klotho is the co-receptor that lets the hormone FGF23 do its job, keeping phosphate and vitamin D in balance. It also dampens several aging pathways at once, including TGF-β, IGF-1, Wnt, and NF-κB, which drive inflammation, fibrosis, and cellular senescence.
Where it acts
The kidney makes the most Klotho of any organ, which is why kidney health is central to its biology. A soluble form also circulates in the blood and is studied for effects in the brain, where higher Klotho tracks with better memory and processing speed.
What people notice
This is studied mainly for the long game, healthy aging, cognition, and kidney support, rather than something you feel in an afternoon. In animal work, a single dose improved memory for up to two weeks, but human effects are not established.
Honest caveat: almost all of this comes from animal and lab studies. The headline cognition result is from aged monkeys, and human trials are still in the planning stages. Klotho is not an approved medicine and is sold strictly for research use only. Curiously, lower doses worked better than higher ones in that monkey study, which underlines how little is settled. None of this is medical advice, talk to a licensed provider before starting anything.
How to take it.
Klotho is a recombinant protein, given as a subcutaneous injection into fat with a tiny insulin needle. It isn't an oral peptide, the protein doesn't survive digestion, so the injectable form is what research uses. The routine is below; for cycling and timing, see the full guide.
Reconstitute the vial
Add bacteriostatic water down the side of the vial (a 1mg vial + 1mL = 1mg/mL, which is 1000 mcg/mL). Let it dissolve. Swirl gently, don't shake, proteins are fragile.
Draw your dose
On a U-100 insulin syringe, pull to your unit mark. A 35 mcg dose at 1000 mcg/mL is about 3.5 units (0.035mL). Use the calculator if you're unsure.
Pinch and inject
Swab with alcohol, pinch a bit of fat, insert at 45–90°, push slowly. Subcutaneous into the belly is simplest. Klotho is dosed by body weight, so confirm your number first.
Rotate your sites
Move to a different spot each time so no area gets sore or lumpy. Store the vial in the fridge between doses and keep it out of light.
The easiest spots are the belly (about 2 inches either side of the navel), the love handles, the front of the thigh, and the back of the upper arms. Rotate every injection.
Don't do the math, let the calculator do it.
This is Klotho's typical setup, already worked out. Change any value and the draw updates instantly.
Typical Klotho dose: roughly 10–35 mcg per kg of body weight, which for many people lands around 0.5 to 2.5 mg per dose, given subcutaneously once or twice a week in short cycles. Note the research hint that lower doses may outperform higher ones, so people tend to start low.
How to cycle Klotho.
How long people run Klotho, when to take a break, and the honest reasoning behind it.
Run in periodic courses; see the guide for timing.
A cycle just means a defined run of time on the peptide, followed by a break. For Klotho the common pattern is a short cycle of a few weeks, once or twice weekly, then time off, rather than running it indefinitely.
Why not just run it forever? Mostly because the long-term human safety data does not exist yet, and Klotho touches powerful systems like growth-factor and inflammation pathways. The cautious approach is a focused block, then a break.
- Keep the schedule simple, once or twice a week at roughly even spacing through your cycle.
- Start at the low end of the dose range rather than the top, given the research hint that less may be more.
- Take a real break after a cycle before considering another. Any concerns are a conversation for a licensed provider, not a forum.
Want the full picture, on and off periods, the washout, stacking, and keeping your results? Read how peptide cycling works →
What's actually in the vial.
For one of these vendors we link the per-batch certificate itself, and the purity below is read straight off it. The rest link to the vendor's general lab-results page. We don't run the labs ourselves and we don't show a purity number unless it's printed on a certificate we link, so you can open the document and check it against the batch yourself.
| Vendor | Purity (per COA) | Batch / report | Certificate |
|---|---|---|---|
| BioLongevity Labs | 99.71% | KLOTHO | View COA ↗ |
What people pair it with.
Klotho is usually run as the anchor of a longevity protocol, layered with peptides that target different aging pathways.
Healthy aging
A systems approach to aging. Klotho works on the FGF23 and inflammation axis, Epitalon on telomeres, MOTS-c on mitochondria, and NAD+ on cellular energy. The combination people reach for to cover several aging pathways at once.
View stack →Cognition support
A cognition-leaning trio. Klotho is studied for memory and processing speed, Epitalon for sleep and circadian rhythm, and SS-31 for mitochondrial support in energy-hungry tissue like the brain.
View stack →Kidney support
A leaner pairing aimed at the kidney and metabolic side of Klotho biology. MOTS-c adds the mitochondrial and metabolic angle on top of Klotho's phosphate and anti-fibrotic role.
View stack →In the same corner.
Other longevity and anti-aging peptides people compare against Klotho.
Questions, answered straight.
Is Klotho legal?
Klotho isn't an approved drug, and it isn't sold for human use. The vendors we compare offer it strictly for research use only. It is not specifically named on WADA's prohibited list, but anything that influences growth factors and aging pathways is a grey area, so competing athletes should be cautious and check current rules. Laws vary by country, so confirm what applies where you are.
What does research use only actually mean?
It means the product is sold for laboratory and research purposes, not as a supplement or medicine for people. It hasn't been reviewed or approved for human use by the FDA. We aggregate prices and public lab data so you can see the landscape; what you do with that is between you and a licensed provider.
How do I store it?
Keep the sealed, freeze-dried vial in the fridge, and out of direct light. Recombinant proteins like Klotho are delicate, so once you mix it with bacteriostatic water, store it refrigerated and use it within a couple of weeks. Don't freeze a reconstituted vial and never shake it.
How often do people dose it?
There is no established human protocol. Research-style use is roughly 10–35 mcg per kg of body weight, given subcutaneously once or twice a week in short cycles. Because the monkey study found lower doses worked better, people tend to start low. Use the calculator to turn your vial and dose into exact units.
Why is Klotho so much more expensive than other peptides?
Klotho is a large recombinant protein, not a short synthetic peptide, so it is harder and costlier to manufacture at high purity. That is why a 1 mg vial can cost far more than, say, a milligram of a small peptide. Compare purity and lab data, not just the headline price.